Granulation section

Production
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cretical point in granulation section

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plz tell me about cretical point in granulation

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how to calculate capacity of RMG and FBD

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Critical point in Wet granulation are:

  1. Binder addition time
  2. Kneading time
    3.Impeller and chopper mixing Time and RPM
    4.Impeller power (Ampearage reading-End point estimation)
    5.Total granulation Time
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Mr asifvexpkaind well in addition
Wet mill speed
drying time
dry sieving particle size
lubrication mixing time is very critical n b 3 -5 min

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sir it is necessary to use separate filter bags for each product in drier of wet mixer???

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In advanve FBDs SS filters are fitted wich are washed after product changeover.
In conventional FBD where fingr bag is used it is difficult to manage 200 filterbags if u hav 200 products.
So filter are are used acordingc to drug classes e.g
general products,quinolones,psychotrophic etc.
Frequency of filter bag change is determined by validating the processes n bag condition.e.g 3 mnth ,6 mnth 1 yrs etc

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Its is not neceessery to use seprate Bags for each product.

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Sir what are the reasons for FBE finger bag damage,please mention briefly.

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  1. Abrasive texture of product.
  2. After Maximum usage period.cleaning and usage cycles…
  3. Hot air inlet air pressure variation and volume
  4. Improper Handling, storage of filter bags.

Thanks

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12

Can anyone explain the addition of procedure of binder solution?
how long should it add? how many steps?

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Thank you sir

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Binder addition time depend on qty of binder.
it should be added gently.
In high shear add in a single stpep.
In low shear may be aded in steps after breaking lumps manually.

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