Assay differebce between auto titrtaor nd HPLC
Auto Titrator is chemical method to determine Assay , and HPLC method is chromatography method to determine Assay,
HPLC Method is better with compare to Titrator method.
titration is an direct and absolute way to determine the content of your sample, whereas HPLC is an indirect and relative method to determine content. A titration method is never stability indicating, HPLC does have this option should you develop you method in such a way.
To establish the actual content of your sample, titration gives you the most accurate result but only if you do not require stability testing since it cannot distinguish between API and impurities.