what is the wet granulation hold time period ???
if breakdown raised after wet granulation or before drying of particulare equipment …so we have to do and what is the recommendation for wet granulation as other risk factor…
Every product may have different hold time period. Therefore, you should determine the hold time period of particular product by holding the product.
yes sir,but for wet granulation any hold time period applicable or not??? what is the time period??
Hold time studies are done during validation of the product in stages of wet granulation drying and after sizing and milling of granules after that its determined .
Every product may have different hold time period depending upon API stability, period of hold, mainly bioload get increased suddenly. Therefore, you should determine the hold time period of particular product by holding the product.