How we can perform visual inspection of eye drop filled in amber glass vial or plastic container.
i thnk visual insppection of solution in closed plastic container is not possible.solution is filtered before filling and bulk solution can be inspected before filling for its clarity.
after filling to chek visual clarity droper should be opend n pour sol in glss cylinder to chk its volume n clearity.
Visually plastic droper can b ckecked for cap sealing,leakage etc.
light obstruction method may b optional
USP 1790, it is suggested there to enhance the illumination of visual inspection hood to 10,000 Lux and to possibly screen the containers from the back when testing brown glass or plastic containers as a visual control for these containers is difficult to conduct.
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But 10000 lux is very high intensity and it may give bad effect to eye.
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so whats the routine practice for visual inspection?
normaly in a cylinder during vol chk cleariy is chekd?
There is no possibility to visually check particulate matter in eye drop plastic container.
Hello Rakesh, and welcome!
When dealing with practically opaque containers, where it is not possible to visually inspect the solution for particle matter, it is recommended to do the inspection in a previous stage (if possible) or to perform sampling of vials/bottles and transfer the solution to a clear container for further inspection. This process must be done in a controlled environment to avoid particle contamination that could cause false positives.
However, if the container is translucent, as for LDPE plastic ampoules, it may be possible to do the inspection at higher light intensities, and may require longer inspection time to effectively identify particles. This process should be characterized and validated.
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