Total Amount Calculation

Production
1

Each 100 ml solution contain 0.5gm w/v Cholorohexidine gluconate. What amount of Cholorohexidine gluconate will required if the Batch size 1000 Liter?

2

the answer is 5000 gm (5 kg) of “Chlorhexidine” gluconate

the calculation is 0.5 * 1000 * 1000 / 100

Is it clear ?

3

I Got it but the problem is Density of Cholorohexidine gluconat will be added in this calculation?

4

You need 0.5 % W/V solution whose volume is 1000 liter

So the needed quantity of the substance is 5000 g

Please Explain why density should be added to the calculation ?

5

You may also need to consider % purity or concentration of Chlohexidiene Gluconate. Are you using Cholrhexidine Gluconate solution or solid powder ?
If it is a solid powder then what is the % purity?
If it is a solution then what is the concentration of this solution?

6

I am not sure about it. If the active is in Liquid State what will be the total amount? There are need to consider the density?

7

I know that. The point is if the active is in liquid form there are need to be calculate the density also?

8

The density does not have importance here

If the API is “pure liquid” which is miscible with water and you want to prepare 0.5 %w/v aqueous solution of the API whose so that solution volume is 1000 liter

1- Weigh 5 kg of the API
2- Put it in the preparation tank
3- Complete with water to “total” volume of 1000 liter

Is it clear ?

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9

Thank u…

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