How u can sterilize manufacturing tank.
Sterilisation of manufacturing is applicable if we are performing product sterilisation into it, it can be done by online programmed SIP method. With Set temperature ex-124 C for 35min (As per engineering and validation).Also it requires pressure and leak test of vessel before proceeding for SIP.
for asceptic preparation. SIP for manufacturing vessel is not applicable. Since we have aseptic filtreation after manufacturing process, here storage vessel , transfer line and filling machine will be subjected for SIP.
Is pre vacuum cycle required in SIP.?