Selection of LOD or MC for last inproses test?

We are conducting the last operation in API Prossessing method that is LOD Or MC… What is the difference between both selection of last operations…

Manul pH

Moisture content plays a major role for the growth of microbes and is MC is more in a product is susceptible and provide optimal environment for growth of organisms. Also MC enhances the degradation of API and may lead to failure for assay and generation of impurities

Review flow chart and ROS,which solvents are using for the process of manufacturing accordingly your product might be solvated with that solvent.For quantification of product you should consider this.

LOD and Karl Fisher are primary methods of Analysis for determining moisture content

Using Halogen (or IR) moisture analyzer is a secondary method of Analysis for determining moisture content, so it needs standardization of its parameters (Drying temperature, Drying profile and shut off criterion, Sample size) depending on a primary method


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