Role of nitrogen blanket

What is the role of nitrogen blanket during manufacturing of liquid orals?

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Nitrogen blanket is used for those product where the properties of product may be changed due to presence of oxygen.

Nitrogen gas (chemical symbol N) is generally inert, nonmetallic, colorless, odorless and tasteless.

Nitrogen gas provides an inert atmosphere if it is used as a ‘Blenket’. It replaces atmospheric air (and Oxygen) therby the product is protected from atmospheric oxidation. Generally, Nitrogen blanketing is done to protect the sensitive active ingredients from oxidation in oral liquid products. For example Vitamins (Vitamin A, D, E, K & other B-complex co-factors and co-enzymes).

Examples of nitrogen gas used in pharmaceutical manufacturing processes include:

Nitrogen blanketing reduces the presence of oxygen by replacing it with nitrogen. This prevents rapid oxidation, corrosion, and rust; suppresses fire; helps prevent combustion; and otherwise ensures that that high purity pharmaceutical ingredients remain pure during manufacturing.

Nitrogen Purging
This is a widely used technique that removes oxygen from packaging before sealing to help preserve and protect the product during transport, as well as protects again airborne contamination. Examples of items frequently packaged with nitrogen gas include blister packaged pharmaceutical products, test kits for physician offices, blood supplies, specimen containers, and sterile medical devices.

Product Transfer
In pharmaceutical manufacturing, nitrogen is frequently used to move a reaction mixture from one vessel to another. Using a safe, inert gas to transfer liquid or powder pharmaceutical materials is crucial as they can be hazardous if improperly handled. Many pharmaceutical ingredients can be damaged or even explode if allowed to contact oxygen or water vapor.


Useful info Sir…

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You are welcome…

Sir u explain it Very clearly and shortly

Thanks for your feedback. You are welcome.

Very nicely explained. thanks for the reply sir

You are welcome…

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Hello, very good explanation, maybe you could help me to resolve this doubt, during the analysis of Nitrogen in the GC by USP, what System Suitability would be necessary to comply?

Thank you everyone. Very good information. Helped a ton.

You are always welcome.

I was looking for some words on hooded burrito blanket for my university project, here you have shared very good information, thanks a lot.

Thanks for your feedback.
You are always welcome.