Process validation ( hopper challenge study)

Quality Assurance
#1

Why Hopper Challenge Study Is Performing During Process Validation?

#2

To check effect of vibration of machine on weight of tablet or flow of blend or powder.

#3

So how can I do it
You mean that i do it by challenge in hopper capacity as a full, half and minimum load?

#4

Yes. To evaluate effect of vibrations during compression on blend uniformity, hopper study shall be carried out.