Pharmaceutical Equipment's Capacity

How to Calculate the capacity of following Pharmaceutical Equipment’s:-

  1. F.B.D
  2. RMG
  3. Auto-Coater or Coating Pan.

Please elaborate in details with calculation.


To Determine capacity in kgs the density of a powder is measured n then multiplied by Liters.
Capacity iñterm of liters remain fix but in kgs vary depending upon density of powder.
For maximum mixing capacity usually 70-75%is taken and results r validated.
Minimum capacity is also determine by validating the results.
Capacity calculation
Determine capacity in term of liters,for this add measured volume water in RMG say it is 400 liters.find density of powder say it is 0.85.then
75%of it is
So full capacity is 340kg maxium mixing capacity is 255 kg.


How to determine density of powder?

Bulk density
add weighing amount of powder in measuring cylinder n note volume
200 gm powder n vol is 300 ml


Thanks Sajjad sir.

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well come

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Hi sir good evening
Sir can you please teach me about
How to decide batch size of the product and how to decide lot

batch size is deceided on basis of equipment capacisty

Batch size is decided based on equipment capacity and also market requirements.
For deciding ‘Lot size (sub-lots)’ and number of sub-lots in one batch again limiting factor is equipment capacity. For example,

  • If granulation capacity (Smaller size RMG) is small then we can do granulation in many sub-lots in one batch. And then combine dried granules from all sub-lots for lubrication and make one batch for further compression in to tablets.
  • Similarly, if coating pan capacity is small then we can do coating of tablets of one batch in many sub-lots and then mix coated tablets from all sub-lots to make one batch for packing.
  • Only one aspect is to be ensured that each sub-lot must meet in-process product specification before mixing all sub-lots and its further processing.