May i know how to check the pH of the Topical dosage form (Cream, Ointment, Gel etc.,).
Whether it can be checked by
1. Dipping the Electrode in beaker containing Dosage form (or)
2. The dosage form have to be dissolved in water (2 gm of sample in 10 ml of water).
If step 2 can be used then, there is a lot difference between the pH of sample that was solubilized in water to pH of sample to which electrode was directly dipped.
Kindly clarify this question…Thanks in advance…