You did not mentioned that filling line is in O-RABS or C-RABS. Your all activity is directly depend upon what type of filling machine you are using. Assessment of risk also varies. Its good to included all major and critical interventions during media fill, but for every intervention proper justification and historical evidence is required. For example: Planned power shut down intervention, now-a-days almost all companies use LAF supported by UPS so justifying this intervention is very tough to regulator as impact will be very high, and it should be supported by various studies. Just keep in mind, any critical intervention which require some major adjustment or major cleaning inside the area, all exposed vials (unstopped) has to be removed (Always). Risk assessment should always be available to justify your interventions.