LOSS ON DRYING -effects on product

Dear All,

i would like to know detail about factor LOD

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the question needs to be more clear

you can explain As LOD role or process in granulation…

Lod in granules play vital role
If LOD is high it shows high moisture level in grains and called under drying which results in sticking/picking.
If LOD is LOW below limits called ovr drying results in excessive fine,more loss,capping and lamination.
LOD should be in define limit determine during validaton


Dear shivraj,
LOD is an key factor in granulation Process i.e. if LOD is low the problem in compression occurs like Cracking, Capping, Capping
If LOD is high it means moisture content in granules is more so there may be the chances of Sticking . Keep the LOD as per BMR.