Hello,
Has anyone seen brown spots on metoprolol tartrate tablets in the stability chamber of 75%RH and 40 degree celcius? I guess it might be due to the lactose monohydrate we use in our formulation as an excipient which is uptaking moisture, but my colleagues think it is due to the reaction between lactose monohydrate and metoprolol tartrate.
what are your opinions?
I appreciate your helps in advance.
Respected @Arsh ,
Yes, i agree with the point about what your colleague said,
Since Metoprolol tartarate have amino group which will react with lactose monohydrate to form Maillard adduct (Refer - Handbook of Pharmaceutical excipient) which lead to this brown spots over the tab. Hope you could find alternative excipient .
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