What is the difference between hardness and friabilty ?
Hardness and friability are both physical characteristics used to describe the properties of materials, especially in the context of pharmaceuticals and solid dosage forms like tablets. They are distinct attributes with different meanings and purposes:
- Definition: Hardness refers to the resistance of a material to deformation or indentation. It is a measure of how easily a material can be scratched, dented, or compressed.
- Measurement: Hardness is typically measured using instruments like a hardness tester. In the context of pharmaceuticals, the hardness of tablets is commonly assessed using a tablet hardness tester, which measures the force required to break or deform the tablet.
- Purpose: Tablet hardness is crucial in pharmaceuticals because it can affect factors like tablet disintegration, dissolution, and the ease of swallowing. It’s used to ensure the quality and durability of tablets.
- Definition: Friability is the tendency of a solid material to break down into smaller pieces or fragments when subjected to mechanical stress, such as tumbling or agitation. In the context of pharmaceuticals, friability is used to assess the susceptibility of tablets to chipping, cracking, or breaking.
- Measurement: Friability is typically measured using a friability tester, which involves placing a sample of tablets in a rotating drum and subjecting them to controlled mechanical stress. After a specified number of rotations, the tablets are examined for damage or fragmentation.
- Purpose: Friability testing is essential in pharmaceuticals to ensure that tablets maintain their structural integrity during handling and transport. It helps assess the robustness of tablets and their ability to withstand mechanical stress.