Increasing or Decreasing Room Differential Pressure possibilities


(Vamsi Sagar) #1

Dear all and Respected sirs,

Can you please suggest what are the possibilities of increasing or decreasing of Clean room Differential pressures for sterile and non-sterile areas

Please suggest


(Ankur Choudhary) #2

What do you mean by possibilities? Limits of differential pressure and ACPH are given in regulatory guidelines. What confusion do you have?


(Vamsi Sagar) #3

Thanks for your quick responce
Chances for getting high and low differential Pressure
For Example: If Return filter clogged leads to High differential pressures


(Manoj Singh) #4

Room pressure will decrease in following cases-
1)if terminal hepa filter is chocked.
2) blower rpm is low.
3)if any leakage from door gasket.
Room pressure will increase in following cases-
1)if terminal hepa is ruptured or leakage from mounting.
2)blower rpm is high.
3)return riser is cloggged.
4)any equipment is placed infront of riser.


(Manoj Singh) #5

What will be happend if blower of return air is not working due to any fault.


(Manoj Singh) #6

Area may be contaminated.room temperature will also increase.suffocation in area.