If the Batch yield is low...How to increase it?

Quality Assurance
1

We are getting low yeild for batches …how to increase it ?

2

In case of liquid injection
Reduce the filtration loss
Reduce the particulates contamination
Control rejection during filling and sealing.
Investigate the cause of high rejection

3

For Solid dosage

  1. Investigate and draw CAPA. Act accordingly.
  2. Check LOD/Moisture Content of materials. Add calculated amount

For Sterile

  1. Try to reduce filtration loss.
4

For sterile preparations like injectables
Firstly find out the root cause at which stage you are getting higher wastage and then work.accordingly…

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5

First of all deviation shall be raised for the subject matter, then investigation should be done.
Root cause analysis can be done with Ishikawa fish bone diagram considering, 6 M (Man, material,method, Measurement, machine, Mother nature).5 Why analysis shall be done.
followed by Corrective action to be taken to overcome the yield loss

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6

In case of low yield Ist type of rejection must be point out for this purpose throughly checking of every step is required, Than make practical measures for vanishing these rejections.

7

Is the process validated?.. what is your target %yield acceptance?

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