Hi, im currently working on stability studies and need to simulate the packaging system of a fiber rum + Inliner, but in a much smaller scale (ca. 1 liter). Has anyone found a practical surrogate packaging that mimics the behavior of a fiber drum more realistically, especially regarding: Moisture exchange/hygroscopic impact, closure systems that simulate the non-hermetic clamp ring.
Any advice, shared experiences or product suggestions would be greatly appreciated.
Yes please. It is possible to simulate the packaging fiber drum, plus inner liner and lid with clamp ring to enable it to be used for conducting stability studies of APIs or similar intermediate materials or drug products. Please contact the supplier or manufacturer of fiber drums that supply those for the packing of such materials. And provide them with specifications for the same and the dimensions required by you for conducting stability studies. The supplier/manufacturer will definitely supply simulated fiber drums to you.
Let us look at it like this:
What does a fibre drum offer as a pack?
Point 1, has no relevance to stability study.
Ponts 2 & 3: We can establish equivalence of some other material like glass or HDPE or Polypropylene container of reasonable thickness.
Other considerations can be (a) material of contact and (b) head space.
The first can be mimicked by using a liner or inner pack; the second, by thoughtful selection of container-size and fill-quantity.
In essence, there may or may not be a ready-made surrogate container available, as you are looking for. But you can scientifically justify your own selection.
Hope, this helps you. Good luck.