How to increase the flowability of a powder without decreasing its dissolution

Production
1

please reply kindly
:slight_smile:

1 Like
2

Dear @shadi , flow of a blend depends on many factors like particles size of granules , fraction of granules and fines in the blend , amount of lubricants in the final blend . So the whole process is said to be validated only when the sample after compression or coating passes the DT and Dissolution Tests .If the Dissolution tests fails than we have to change any of the above mentioned parameters for increasing or decreasing the dissolution profile of the sample.

3

Use Aerosil or reduce the granule size whichever is apt for your formulation.

4

grain size should be appropriate.
grain to fine ratio should be appropriate.
more fine retard flow.
use of glidents improve flow.
if manual hoopers are used then increasing the distance bw feeder n hooper base increase flow.
vibrator in hoper incrase flow.