How many types are there for maintaining differential pressure in pharmaceutical industry?

Types of differential pressures used in pharmaceutical industry

This is an unclear question

Sir I am trying to say that to maintain differential pressure how many types are preferred in pharmaceutical companies?

Maintain differential pressure and how many types do not make sense.

The pressure differential between adjacent clean rooms or clean zones of different cleanliness level should lie typically in the range of 5 Pa to 20 Pa, to allow doors to be opened and to avoid unintended cross-flows due to turbulence. This is the most important rule. You do not want air from room A to enter room B or the other way around.

I think u r trying to ask about type of buffer
its of 3 type

Hello Sajjad,

Thank you for this information.
I am looking into it also :slight_smile:

Cascade Airlock: These airlock are very common having higher pressure on one side and lower pressure on another side. In this system positive air pressure flows from the higher pressure internal zone to be airlock and from the airlock to the lesser lower pressure grade area. This prevents to entry dust and contamination from outside to airlock and from airlock to inner side.
Any manufacturing facilities where the product requires protection from particulate but the people outside the clean-room do not need protection from the product in the clean room.
2.0 Bubble Airlock: These types of airlock having higher pressure inside the airlock and lower pressure both outside. It creates a barrier where contaminants within either area pushed back into their own respective areas.
Used in, areas where the product needs protection and the people external to the cleanrooms require protection from the product, to reduce the possibility of viable articulate from entering the lesser pressure clean-room. Area such as higher potency, compounding areas terminal sterilization is not an option.
3.0 Sink Airlock: Airlocks having lower pressure inside the airlock and higher pressure on both sides of the airlock. This airlock pulls air from both adjacent areas creating a low pressure barrier and reduces the opportunity of contaminations passing to the internal zone.


In many research facilities, substance that are experimented on are highly dangerous, and it is essential to keep them from being exposed. During a few type of production process in a clean-room, air from a contaminated area has to be contained one place.
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