Granulation Technique

What r critical parameters of granulation?

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Following r parameters
Kneading time
binder qty
binder addition time
Chopper sped
Mixing speed etc

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Wet Granulation (RMG)

  1. Pre-binder addition mix time
    Blend uniformity Flow, Moisture
    content Particle size and distribution
    addition Granule size and
    distribution Granule strength and
    uniformity Solid form
  2. Impeller speed and ON time
  3. Chopper speed and ON time
  4. Binder fluid temperature
  5. Binder addition rate and time
  6. Post-granulation mix time

Spray Granulation (FBE)

  1. Spray nozzle type and location
    Blend uniformity Flow Moisture
    content Particle size and distribution
    addition Granule size and
    distribution Granule strength and
    uniformity Solid form, Moisture
    content, Residual solvents
  2. Binder addition rate and time
  3. Bowel temperature
  4. Fluid bed granulations Mixing time
    Spray nozzle (type/quantity/
    pattern/configuration)
  5. Binder fluid temperature
  6. Inlet air flow rate, volume,
    temperature, and dew point
  7. Exhaust air temperature,
  8. Shaking intervals
  9. Product temperature
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Dear sir if chhoper speed and binder quality is more means what will be happend.

if chopper speed is very high a good quality grain will not b produced extra high speed break the grain n more fine will produced after drying.

After drying, if I find granules very hard n compact that means DT will be higher. Is there any technique to solve it?

may use lower level mesh if flow is not affected during compression

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