Friability test

(PRAVEEN GOLASANGI) #1

Why friability is required for uncoated tablets?
Strength of the tablet can be increased by increasing the hardness…But why friability?

(Ankur Choudhary) #2

Friability is done to test the strength of uncoated tablets but not to increase it.

(Pharmabuddie) #3

Hi Praveen,
Just to give you a quick insight that why friability is done so that you can have a better understanding.
Friable is a French word which means “easily crumbled or broken” including Latin origin of Friare which means “rub away, crumble into small pieces”. So from the definition it is clear that it is on the other way we are checking the hardness only, so Why Friability testing, why not hardness testing only?
This test is carried out in un-coated, compressed tablets which has the tendency of getting chip off, crumble or break off during handling and subsequent storage (which also include transportation of product). It is not only important for dispersible tablets where hardness cannot be increased, but to those tablet as well which are already have proper hardness maintained. This is due to avoid tablet to exhibit any unacceptable capping or excessive wear on the tablet edges or logo while undergoing Coating operations. The tablet hardness cannot be increased beyond the limit as there will be impact on dissolution and disintegration parameter and it will have larger impact on biological activity of the drug product.

Hope I answer your query, for more details on friability please refer following references.

USP General Chapters: <1216> TABLET FRIABILITY
USP General Chapters: <1217> TABLET BREAKING FORCE
http://apps.who.int/medicines/publications/pharmacopoeia/TabletFriability_QAS11-414_FINAL_MODIFIED_March2012.pdf

3 Likes
(PRAVEEN GOLASANGI) #4

Very informative…Thanks for your valuable reply

1 Like
(PRAVEEN GOLASANGI) #5

Dear,
May i know the friability limit or target for effervescent/orodispersible tablets!?

(suman pattanayak) #6

Dear all,
I have an inquiry…
What is the tablet dropping angle in friability test apparatus???

(PRAVEEN GOLASANGI) #7

Angle of about 10 degrees with bench top and tablets should fall freely from the top

(revanth pade) #8

is the friability test applicable only for uncoated?..
dont we test friability for coated tablets ?

(Sajjad Ahmad) #9

it is used only for uncoated tabs

1 Like
(Sajjad Ahmad) #10

Friability is done for uncoated tabs bcz of following
Not to chip,break,cap during coating.
Not to break during blistering.
Not to break during transportation.

1 Like
(Dr. Ahmed Mohamed Awad) #11

1 Like
(Meenakshi Gupta) #12

Thanks.very nicely explained