End points determination

(Md. Saifullah Khan) #1

How do I determine end points of RMG, FBD, Double cone blender and tablet coating?

(Sajjad Ahmad) #2

Emperage reading
Physical examination
By film weight gain.

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(Dr. Ahmed Mohamed Awad) #3

Wt gain is usually used in sugar coating

While in case of film coating the coating solution is usually sprayed until it is all gone (after validating its quantities)

In case of FBD of coarse moisture content determination

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(Sajjad Ahmad) #4

In drug coating wt gain is also checked.
In film coating wt gain range is also chek.
physical appearance,color uniformty etc also checked

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(Dr. Ahmed Mohamed Awad) #5

And of course after finishing coating process there must be IPQC tests (after coat) before primary packing step

(Md.Asif Hussain) #6

Case study: if you find tablet is problem of logo bridging during coating and weight gain is not achieved, what shall be done?

(Sajjad Ahmad) #7

Logo filling and wt gain not achieved may be due to following
High inlet temp.
high bed temp.
low spray rate.
high automizing pressure.
High gun to bed distance.

(Dr. Ahmed Mohamed Awad) #8