what is the effect of lubricant on disintegration time?
Increase of the lubricant concentration in tablet formulation can create a barrier between tablet granules or particles and the disintegrating liquid of interest, resulting in an increase of disintegration time of the tablet.
how it can be prevented?
Optimum amount of concentration validated by R&D team.
minimum mixing at the end
hydroplhilic lubricants eg sodium steryl fumarate may also be used
How increase in lubricant increase tablet hardness?
tablet hardness is decreased