Dissolution problem in clomiphene citrate

Production
1

Can anyone plz tell that which one is the perfect solubility enhancer & permeability enhancer for active clomiphene citrate?
I have tried many time to achieve dissolution of clomiphene citrate but I m failed in the same? The dissolution Limit of clomiphene citrate is 75-80%

2

what’s your formulation?

4

better to use PVP k30 as a binder.
gelatin n starch give strong bounding thats y drug relz is prolonged n results r not achieved.

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5

in current formulation u will have to increase the qty of any of following
SLS
cross-linked pvp
or SSG.
or
reduce granulation time
qty of water added

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6

if u dnt want to chang formulation then try to conduct a trial using more fine sieve?
currently u r using seive no?
ur tab wt?

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7

Currently I m using Sieve 100

8

After drying which sieve is used for grains?

9

30# sieve

10

so should try to change binder

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