Dissolution of clomiphene citrate Tablet

What r the solubility & permeability enhancer for active clomiphene citrate?

Or what might be the changes required to achieve dissolution 80 Limit%?

Last Result achieved upto 65%

Avg wt is 200mg

Formula as follow

API
LACTOSE
STARCH
BETA CYCLODEXTRIN
SLS

IPA+PVPK30 BINDING

30# Sieve Grains after Drying

Lubrication

Mg stearte
Talc
Aerosil
Cross povidone
CCS
SLS

Try to use polysorbate in binder solution

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Sir I already used Tween 80

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try with 3% cross carmelose sodium intragranular n 3% in final blend

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For drying FBD is used or tray dryer?

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Tray dryer

it may also be the reason.bcz tray dryer produce hard granules.

check by using no 40 sieve after drying.

if flow remain good dissolution will be improved


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