Dissertation Topic

Hello everyone,
I work in Quality Assurance at a Pharmaceutical firm for last twenty some years. Recently I applied for PhD. program and my advisor is urging me to come up with a topic that relates to cGMP system that would work in Quality Systems. My problem is I have to come up with a topic so I can base my research on GMP related issues. I thought since we all are colleagues at work maybe you guys can shed some light on a topic dissertation. I can explain why I have not come up with a topic . Pharmaceuticals have cGMP guidelines and those are in most cases black and white. I have a hard time coming up with a topic that would solve a problem. I’d kindly ask if anyone can give me some feedback in this area, Much appreciated .