What is difference between loss on dry & determination of moisture content by karl fischer?
1 Like
In LOD Water content and solvent content are determined while in water by KF determines moisture content only.
5 Likes
LoD: water content + solvents percent
Kf mc: we get only water percent
2 Likes
karl fischer method(titration) is a method measures only the water content in a product sample where as loss on drying is a method to designed to measure the amount of water and volatile matters in a product sample when the product sample is dried under specified temerature.
3 Likes
I prefer MC in dealing with wet-granulated powder because it gives a direct info on the moisture content of the granules after drying.
You may use LOD in cases where the granulation vehicle is not water or is not entirely water.
1 Like
what are the possibilities to get M.C results below the specification limit.
what are the possibilities to get MC results low in finished product
LOD is a physical test. Water of crystallization will not be removed. KF is a chemical analysis any H2O present will react.
2 Likes
May be over drying water content result comes low
In LOD = we can determine Water + Organic volatile solvent content
in KF = We can determine only Water content
1 Like