Converting In vitro data (dissoultion profile data) to predict In vivo (Plasma drug profile)

How to predict in vitro data collected from dissolution profile, for a new paracetamol formulation extended release tablet, to get in vivo data i.e profile drug concentration profile. I read some steps available on the internet but I need step by step solution for the same.

If you have not already found the reference, here is link for converting dissolution results to plasma drug levels ( Also, I will be giving a seminar on the topic next month in Boston, MA (link is There are plans for webinars on the topic so keep an eye for it. I also write a blog on the topic of drug dissolution testing ( which also provides information on the subject.
Best of luck.