Column management

Dear all,
Can we use C18 column in place of C8 column in analysis?

You will have to perform the following tests by using C18 HPLC column instead of C8 column.

  • System suitability
  • Analytical Method validation as per ICH Q2(R1/R2) guidelines.

If the above aspects are satisfactory meeting the acceptance criteria then you can use C18 column for routine samples (batches) analysis.

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