Can we use C18 column in place of C8 column in analysis?
You will have to perform the following tests by using C18 HPLC column instead of C8 column.
- System suitability
- Analytical Method validation as per ICH Q2(R1/R2) guidelines.
If the above aspects are satisfactory meeting the acceptance criteria then you can use C18 column for routine samples (batches) analysis.
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