Coating problem

(Elena Ponkratenkova) #1

Hi colleagues,

could you give me some advice how sort out the problem with coating. About 1.5 % coating tablets have the following defects: tiny uncouting (white) spots into logo and on the edges of tablets. We tryed working with different parameters and their combinations (high or low: pan speed, spay rate, atomising and spray pressure). It didn’t make sense. Сomposition of coating suspensiion: hyprolose, titanium oxide, ferric oxide and macrogol.

(Sajjad Ahmad) #2

check out the concentration of titinium and macrogol.higher conc of these may case the said defect.

(Rahul Kumar ) #3
  1. You should be Properly Colloid the Coating Solution and passed from Muslin cloth (#200 to #300).
  2. Replace your coating solution to Ready made film coating materials (like Colorcoat, Opadry, Aquadry and Bharat Coat).

KAPL, Dharwad (Karnataka)

(Elena Ponkratenkova) #4

Dear colleague,

thanks a lot for your answers, but it’s impossible to change the concentation of ТiO2 and macrogol and replace our coating solution to Ready made film coating materials

(Sajjad Ahmad) #5

what is the previous batch history?u faced this problem just in this batch or faced same problem in all previous batches?

(Elena Ponkratenkova) #6

in all previous batches.

(Sajjad Ahmad) #7

Then surely its coating formulation problem.

(Sajjad Ahmad) #8

while coating operation coating suspension is subjected to continous stirring or not?

(Rahul Kumar ) #9

You should pass all materials through 100mesh and use 0.2% tween 80 as wetting agent for better dispersibility. This will solve the problem.

(Elena Ponkratenkova) #10

continue stirring but very slowly

(Elena Ponkratenkova) #11

I cannot use tween because it’s not in formula.

(Rahul Kumar ) #12

Try to pass all materials through 100mesh

(Rahul Kumar ) #13

Can you provide more details about coating equipment make and capacity.

  1. Run your product in other available autocoater
  2. Procure same materials from different approved vendor/ Branded Coating excipients

(Sajjad Ahmad) #14

can you share pics of defected tabs?

(Elena Ponkratenkova) #15

(Simon Gooden) #16

Have you checked the spray pattern? Made changes to pressure, ect…?

(Sajjad Ahmad) #17

It seems to be peeling of coating film?

(Sajjad Ahmad) #18

Coating solvent is water or organic?

(Sajjad Ahmad) #19

Tablet bed temp?

(Elena Ponkratenkova) #20