I did read the pharmaguideline article about concentration of API (Identification of Worst Case in Cleaning Validation). It says the product having higher API concentration is the worst-case.
Some medicine has paracetamol api 500 mg plus other api maleate of chlorfeniramine 4 mg. So is the worst case the paracetamol api ? I tried to find ich cleaning guide, gmp cleaning guide. They don’t say nothing about higher api concentration for worst-case how do we assume that ? I’m studying about this topic and i got very curious. Thanks.