Cleaning room surfaces after wet contact time of diluted disinfectant

(Dr. Ahmed Mohamed Awad) #1

In EU Annex 1 Draft 2017 the following is stated:

"Disinfection

5.31 The disinfection of clean areas is particularly important.

Cleaning programs should be effective in the removal of disinfectant residues ." End quote

http://academy.gmp-compliance.org/guidemgr/files/2017_12_PC_ANNEX1_CONSULTATION_DOCUMENT.PDF

And in current WHO Annex 6 the following is stated:

"3. Sanitation

3.1 The sanitation of clean areas is particularly important.

Appropriate cleaning validation should be carried out to ensure disinfectant residuals can be detected and are removed by the cleaning process ." End quote

So the interpretation of these statements can be as follows:
“Generally after each application of diluted disinfectant on clean room surfaces for the valid wet contact time , the disinfectant residues remaining on clean room surfaces should be removed by cleaning (rinsing) the clean room surfaces (with for example Water or IPA 70% then dried)”

My questions are:
1- Is the mentioned interpretation accurate ?
2- If this interpretation is not accurate what is the accurate interpretation ?
3- If this interpretation is accurate:
what are the dangers of not removing disinfectant residues from clean room surfaces by cleaning (rinsing) after each application of diluted disinfectant ?

Thanks a lot

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(Dr. Ahmed Mohamed Awad) #2

I want to say that my little understanding of the issue is that:

If the routine daily cleaning process is composed of first wet cleaning (without disinfectant) followed by disinfection with “diluted” disinfectant which is then dried leaving no visually obvious residues on room surfaces , there will be no chance for build up of disinfectant residues (since the first step of every subsequent routine cleaning process is wet cleaning (without disinfectant) which will remove any non visually obvious disinfectant residues remaining from the previous routine cleaning process) and always there will be no need at all for cleaning (rinsing) room surfaces after any application of diluted disinfectant for the purpose of removing disinfectant residues.

Am I right ?

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