Cip and cop in cleaning validaTion

Quality Assurance
1

What is meant by cip and cop while performing cleaning validation

2

CIP= Cleaning In Process
COP= Clean Out of Place

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Clean-In-Place (CIP) Method

  • Cleaning of the equipment is performed in place without disassembling
  • Cleaning process may be controlled manually or by an automated program.
  • Very consistent and reproducible cleaning method.
  • Can be validated readily.
  • Being a closed system visual inspection of all components is difficult.

Clean-Out-Of-Place (COP) Method

  • Cleaning of disassembled equipment is performed in a central washing machine.
  • The washing machine also requires validation such as the temperature, ultrasonic activity, cycle time, cleaning operation sequence, detergent quantity dispensed etc

Regards
Rahul Kumar
Karnataka Antibiotics and Pharmaceuticals Limited
Dharwad

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