Significant change in long term stability

[Pankaj_Kumar1 (Pankaj Kumar)]

Is significant change criteria applicable for long term stability??

[upendrapandey3001198 (upendra pandey)]

As I know significant change only applicable for ACC condition but if there are significant change precieve in LT then products can not attain self life period.

[Pankaj_Kumar1 (Pankaj Kumar)]

Thanks for answering but i want more clarity that if we get significant change in LT then what should be next step??