I did not say that there is a guideline to combine the lots during blending/lubrication. This is an industry practice.
Secondly, we can give the same batch number to the sub-lots of coated tablets, only if every individual sub-lot meets the finished product specification. Alternatively, you can provide prefix- A, B, and C to the main batch number of the finished product in order to maintain the identity of individual sub-lot of coated tablets. For example, if you manufacture a batch of tablets (until core tablets-before coating) having Batch number 230805, and you divide tablets of this batch into three sub-lots for coating purpose, then you can give after coating the batch number for individual sub lot (coated finished product packed) as 230805-A, 230805-B, 230805-C. This will ensure the identity of individual sub-lots of coated tablets. It is to be ensured that all the sub-lots must meet the finished product specification when analyzed individually. You may combine individual lubricated granules after compression in to tablets. However, individual lots of compressed tablets must be analyzed separately and must meet the finished product specification, only then you can combine them. It is required to maintain the identity of individual lots of compressed tablets by giving separate batch (sub lot) numbers as I have explained above with an example.
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