Coating susp. procedure


(Sajjad Ahmad) #1

suitable procedure to prepapre coating susp?


(Md. Saifullah Khan) #2
  1. Aqueous system:
    • Weigh the required quantity of coating materials
    • Take the required quantity of boiled and cooled purified water in a stainless steel vessel. The temp. appox. 35°C to 40°C.
    • Stir with propeller stirrer to form vortex. Add qty of coating materials individally in vortex, stir for 5 min.
    • Reduce the speed of stirrer and continue for 40 minutes.
    • Pass solution through 100 mash

(Md. Saifullah Khan) #3
  1. Solvent/ Non Aqueous system:
    • Weigh the required quantity of coating materials
    • Take required quantity of IPA in vessel.
    • Stir with propeller stirrer to form vortex. Add qty of coating materials individally in vortex, stir for 10 min.
    • Add quantity of Methylene Di-chloride and stir continue for 30-35 minutes.
    • Pass the solution through 100 mash open sieve & amp; the material ready for use to coating the tablets.

(Sajjad Ahmad) #4

For some drug coating temp req is 70_80°C.


(Sazu) #5

I want know which is drug name?


(Sajjad Ahmad) #6

Sitagliptin phosphate for drug coating is soluble in hot water at 70-80 °C


(Md. Saifullah Khan) #7

In Non Aqueous system why IPA & MCL both solvent required?


(Sajjad Ahmad) #8

only IPA CAN ALSO BE USED


(Md. Saifullah Khan) #9

than why MCL is also is used?


(Sajjad Ahmad) #10

its may vary compny to compny formulations