How to choose a die for sampling of blender

Quality Assurance
1

How to choose a die for sampling of blender please provide me answer in brief and what formula and terms are applied behind that

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2

Sampling dies are selected according to the quantity to be sampled for the the analysis. Sampling thief is used for the sampling of the blender.

3

But sir ,why smpaling die unit in ml and we mainly use in mg or gm, so how to we use ml die for sampling in mg

4

Please provide formula ,how to select a die for sampling of specific range of dose

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5

  1. Need to find Bulk density of blend…that is already known during trial , scale up or validation run…so can get from F&D research people…or u can find with Bulk density simple formula…

  2. Bulk Density value is in Gm, so convert it in mg, by dividing with 1000.

  3. Now, Formula:

Blend sample requiered in unit die (in mg) / Bulk density (in mg).

Final Value will give die size…u need to choose.

Extra information:
Die size is in CC, and 1 CC= 1ml.

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6

Sir please please simply Write the formula with Example

7

Bulk density =mass/volume

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8

Thanks arpit sir
Regards
mahesh aglawe

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9

I can not find a proper guideline for this but as our routine practice we are following as i describe below- Please correct me if i am wrong

Ex- Suppose we have a unit dose 250 mg.
Now we have to sampling the mass (m) in between 1x to 3x i.e- 250 mg to 750 mg.
Now to calculate the required die size first off all we need to calculate the Density of the bulk which to be sampled.
D= M/V (It will come as mg/ml)
Suppose it is 0.6 mg/ml
Now we have all data so required die volume v=m/d
For 3x quantity the required die volume (V)= 750/0.6=1250 mg/1000= 1.25 cc

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